ABSTRACT
The antihypertensive effect of Minizide(0.5mg prazosin hydrochloride and 0.25mg polythiazide per tablet)was evaluated in 30 patients with essential hypertension with a dosage of one tablet a day for four weeks. The results were as follows : 1) Of 30 patients treated with Minizide, 21 patients(70.0%) achieved normalization of blood pressure and 5 patients(16.7%) had good response. 2) Mean drop in systolic and diastolic pressure were 29.0mmHg and 15.9mmHg respectively in supine position(P<0.005). 3) Mean drop in systolic and diastolic pressure were 28.5mmHg and 16.2mmhg respectively in sitting position(P<0.005). 4) In 14 patients(46.7%) among 30 patients treated with Minizide adverse reactions developed. The most frequent one was postural dizziness(23.3%). 5) Most adverse reactions were transient and tolerable. However, in three patients(two patients with postural dizziness and one patient with dry mouth) the medication was stopped due to adverse reactions.
Subject(s)
Humans , Blood Pressure , Dizziness , Hypertension , Polythiazide , PrazosinABSTRACT
The effect of Minizide(R) (prazosine 1mg and polythiazide 0.5mg) was studied in 34 hypertensive patients (female 16 cases, male 18 cases) at the Department of Internal Medicine, Paik Hospital, In-Je Medical College between July, 1979 and August 1980 for 14 months. The patients didn't take the any drugs for one week before the clinical trial with Minizide(R), and thereafter they took minizide 1 tablet 3 times daily for 2 weeks. The blood pressure was checked before and after the trial in the supine and standing position. The results were as followings: 1) The systolic blood pressure before the treatment with Minizide in the supine position was 196+/-24mmHg and in the standing position 188+/-22mmHg. The systolic blood pressure after the treatment with minizide in the supine position was 148+/-16mmHg and in the standing position 139+/-9mmHg. 2) The diastolic blood pressure before the treatment with minizide in the supine position was 118+/-11mmHg, and in the standing position 113+/-10mmHg. The diastolic blood pressure after the treatment with minizide in the supine position was 87+/-6mmHg and in the standing position 84+/-5mmHg. 3) There was no significant orthostatic hypotension after the 34 patients. 4) There was no changes of laboratory findings after the treatment. 5) 3 of 34 hypertensive patients after the treatment complained of headache, 3 palpitation, 2 edema, 2 drowsiness, and 1 fatigability and 1 patient complained of weakness.
Subject(s)
Humans , Male , Blood Pressure , Edema , Headache , Hypotension, Orthostatic , Internal Medicine , Polythiazide , Sleep Stages , Supine PositionABSTRACT
The effects of Prazosin administered alone or in combination were studied in 30 hypertensive patients at the Busan national University Hospital, Korea, between August 1974 and march 1975. The Patients were studied for up to 6 months; their ages ranged from 17 years to 68 years with mean age 51.4 years; 15 patients were male and 15 female. Satisfactory control of blood pressure was achieved in all patients. The group controlled by prazosin alone had the lowest mean original blood pressures, the group requiring prazosin plus polythiazide occupied an intermediate position, and the group requiring prazosin plus polythiazide plus beta blockade had the highest mean original blood pressures. 6 patients responded satisfactorily to prazosin, alone. In this group the supine systolic blood pressures before and after treatment were 185+/-16 and 150+/-12mmHg respectively; the supine diastolic pressures 106+/-5 and 90+/-3mmHg respectively. The standing systolic blood pressures before and after treatment were 173+/-13 and 134+/-4mmHg respectively; the standing diastolic pressures 102+/-5mmHg and 81+/-6mmHg respectively. 17 patients responded satisfactorily to the combination of prazosin and polythiazide. In this group the supine systolic blood pressures before and after treatment were 197+/-26 and 148+/-16mmHg respectively; the supine diastolic pressures before and after treatment were 121+/-13 and 92+/-6mmHg respectively. The standing systolic blood pressures before and after treament were 188+/-27 and 148+/-16mmHg respectively; the standing diastolic pressures before and after treatment were 110+/-14 and 85+/-5mmHg respectively. The remaining 7 patients responded satisfactorily to the combination of prazosin, polythiazide and a beta blocking agent (tolamolol). In this group the supine systolic blood pressures before and after treatment were 230+/-25 and 181+/-6mmHg respectively; the supine diastolic pressures before and after treatment were 138+/-15 and 93+/-6mmHg respectively. The standing systolic blood pressures before and after treatment were 224+/-24 and 151+/-9mmHg respectively; the standing diastolic pressures before and after treatment were 136+/-12 and 75+/-4mmHg respectively. 5 patients complained of headache, palpitations and general malaise; oedema was observed in 5 patients; 5 patients complained of drowsiness and 5 patients, fatiguability. In each case the side effects were of short duration not lasting beyond 3 days.
Subject(s)
Female , Humans , Male , Blood Pressure , Headache , Korea , Polythiazide , Prazosin , Sleep StagesABSTRACT
The effects of Prazosin administered alone or in combination were studied in 30 hypertensive patients at the Busan national University Hospital, Korea, between August 1974 and march 1975. The Patients were studied for up to 6 months; their ages ranged from 17 years to 68 years with mean age 51.4 years; 15 patients were male and 15 female. Satisfactory control of blood pressure was achieved in all patients. The group controlled by prazosin alone had the lowest mean original blood pressures, the group requiring prazosin plus polythiazide occupied an intermediate position, and the group requiring prazosin plus polythiazide plus beta blockade had the highest mean original blood pressures. 6 patients responded satisfactorily to prazosin, alone. In this group the supine systolic blood pressures before and after treatment were 185+/-16 and 150+/-12mmHg respectively; the supine diastolic pressures 106+/-5 and 90+/-3mmHg respectively. The standing systolic blood pressures before and after treatment were 173+/-13 and 134+/-4mmHg respectively; the standing diastolic pressures 102+/-5mmHg and 81+/-6mmHg respectively. 17 patients responded satisfactorily to the combination of prazosin and polythiazide. In this group the supine systolic blood pressures before and after treatment were 197+/-26 and 148+/-16mmHg respectively; the supine diastolic pressures before and after treatment were 121+/-13 and 92+/-6mmHg respectively. The standing systolic blood pressures before and after treament were 188+/-27 and 148+/-16mmHg respectively; the standing diastolic pressures before and after treatment were 110+/-14 and 85+/-5mmHg respectively. The remaining 7 patients responded satisfactorily to the combination of prazosin, polythiazide and a beta blocking agent (tolamolol). In this group the supine systolic blood pressures before and after treatment were 230+/-25 and 181+/-6mmHg respectively; the supine diastolic pressures before and after treatment were 138+/-15 and 93+/-6mmHg respectively. The standing systolic blood pressures before and after treatment were 224+/-24 and 151+/-9mmHg respectively; the standing diastolic pressures before and after treatment were 136+/-12 and 75+/-4mmHg respectively. 5 patients complained of headache, palpitations and general malaise; oedema was observed in 5 patients; 5 patients complained of drowsiness and 5 patients, fatiguability. In each case the side effects were of short duration not lasting beyond 3 days.